The relation between the activities of endogenous and exogenous β-glucuronidase and primary common duct stones
10.3760/cma.j.issn.1673-4904.2011.05.007
- VernacularTitle:内外源性β-葡萄糖醛酸酶与原发性胆总管结石的关系
- Author:
Yingtian TAO
;
Xiangling MENG
;
Aman XU
;
Gang WEN
;
Congyin TU
;
Zhaogang HUANG
;
Quan XIA
- Publication Type:Journal Article
- Keywords:
Glucuronidase;
Choledocholithiasis
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(5):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of endogenous and exogenous β-glucuronidase( β-G) in the development of primary common duct stones.Method Using modified Fishman method to test the activities of the endogenous and exogenous β -G in 35 patients with primary common duct stones(experimental group) and 11 patients with cystic polypus (control group) respectively.Results The activities of endogenous β -G in the bile of experimental group and control group were (7859.1 ± 738.5 ),(2174.9 ± 348.4 ) U/L(P ＜0.01).While the activities of exogenous β-G in experimental group and control group were (6786.1 ±544.3),(1504.7 ±655.7) U/L (P ＜0.01).In experimental group,there were significant statistical differences in the activities of the exogenous β -G in the sample obtained on the day of operation and 7 days after operation from 13 cases with the acute inflammation [(8935.7 ± 845.9),(2176.1 ± 956.7) U/L]and from 22 cases with the chronic inflammation [(5137.2 ±540.7),(1838.8 ±733.3) U/L],and there were significant higher in the activities of the exogenous β -G in the sample obtained on the day of operation from the acute inflammation compared to those from the chronic inflammation (P ＜ 0.05 ).Conclusions There is obvious correlation between either endogenous or exogenous β -G with primary common duct stones.And the endogenous β -G might be one of the fundamental cause in the development of primary common duct stones.
