Correlation of nonalcoholic fatty liver disease with urinary albumin excretion ratio in type 2 diabetes mellitus
10.3760/cma.j.issn.1673-4904.2011.10.011
- VernacularTitle:2型糖尿病患者非酒精性脂肪性肝病分级与尿白蛋白排泄率的关系
- Author:
Xiaohong CHEN
;
Ji HU
;
Zhimin MA
;
Jixiang DONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Fatty liver,alcoholic;
Urinary albumin excretion ratio
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(10):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the relationship of liver ultrasound class and urinary albumin excretion ratio (UAER) in type 2 diabetes mellitus (T2DM) combined with nonalcoholic fatty liver disease (NAFLD). Methods One hundred and ninety-seven T2DM patients were divided into 3 groups according to the degree of hepar adiposum: group A (66 subjects without NAFLD), group B (63 subjects with mild NAFLD) and group C (68 subjects with moderate or severe NAFLD). Their clinical indexes,UAER and biochemical parameters were measured and compared, the relative analysis of blood fat, HOMA-IR and UAER was done. Results Compared with those in group A, the levels of UAER were significantly increased [(86.49 ± 65.19) mg/24 h vs. (115.16 ± 101.99) mg/24 h vs. (159.45 ± 149.08) mg/24 h,P ＜ 0.05], and the levels of high density lipoprotein cholesterol decreased in group B and group C[(1.21 ± 0.37) mmol/L vs.(1.05 ± 0.38) mmol/L vs. (0.99 ± 0.21) mmol/L,P ＜ 0.05]. Multiple stepwise regression analysis showed that triglyeride was the most important risk factor affecting UAER(P ＜ 0.05). Conclusions There is a close relationship between NAFLD and UAER in T2DM. In the subjects with moderate or severe NAFLD, the UAER increases which indicates that these patients already have capillary vessel injury apparently.
