Observation of curative effect of gastric bypass on type 2 diabetes: a study with eight cases and literature review
10.3760/cma.j.issn.1673-4904.2011.10.003
- VernacularTitle:胃转流术对2型糖尿病患者糖代谢影响的初步观察:八例临床资料分析并文献复习
- Author:
Ying GUO
;
Wenmao YAN
;
Youguo LI
;
Rixing BAI
;
Maomin SONG
;
Liyong ZHONG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Gastric bypass;
Islet β cell function;
Insulin resistance
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(10):6-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of gastric bypass on glycometabolism and improvement of islet β cell function and insulin resistance in patients with type 2 diabetes. Methods Eight patients with type 2 diabetes combined with gastric carcinoma who treated with gastric bypass were studied prospectively. Fasting and postprandial plasma glucose levels, fasting and postprandial insulin C-peptide levels, and body mass index (BMI) were measured right before the surgery and at intervals of 1 week, 2 weeks, 1 month and 3 months after the surgery. Glycosylated hemoglobin (HbA1c) levels were measured before and 3 months after the surgery. The outcome of the diabetes after 3 months of the surgery was also monitored. Results Fasting and postprandial plasma glucose levels decreased (P ＜ 0.05) and fasting and postprandial insulin C-peptide levels increased (P ＜ 0.05) after the surgery. HbA1c levels also decreased (P ＜ 0.05) after 3 months of the surgery. There was no significant change of BMI at all intervals after the surgery(P＞ 0.05). All of the 8 patients reached the total effective standard and 6 patients reached the clinical remission standard after 3 months of the surgery. Conclusions It suggests that gastric bypass can significantly lower plasma glucose levels in type 2 diabetes, which does not depend on the loss of weight. The control of plasma glucose by gastric bypass may be due to the improvement of islet β cell function and increasing secretion of endogenous insulin.
