Control study on the effect of Helicobacter pylori eradication treatment on chronic idiopathic thrombocytopenic purpura

VernacularTitle:幽门螺杆菌根除疗法治疗慢性特发性血小板减少性紫癜的对照研究
Author: Heping YU ; Hai YU ; Min LI ; Qing GU ; Zhixiang SHEN
Publication Type:Journal Article
Keywords: Purpura,thrombocytopenic,idiopathic; Helicobacter pylori; Case-control studies
From: Chinese Journal of Postgraduates of Medicine 2011;34(4):11-12
CountryChina
Language:Chinese
Abstract: Objective To assess the effect of anti- Helicobacter pylori (Hp) treatment on patients with chronic idiopathic thrombocytopenic purpura (cITP). Methods Fifty-nine patients with cITP and positive-Hp were divided into two groups by random digits table:Hp eradication group (30 cases,given a standard anti-Hp treatment) and placebo controlled group (29 cases,received a placebo). The platelet response of two groups was compared after three months' follow-up. Result The platelet response in Hp eradication group (63.3%, 19/30) was significantly higher than that in placebo controlled group (27.6%,8/29 )(χ2 = 7.59, P ＜ 0.05 ), and the increasing level of platelet count in Hp eradication group [ (33.5 ± 21.6)× 109/L] was higher than that in placebo controlled group [(12.6 ± 19.5) × 109/L] (t = 5.52,P ＜0.05).Conclusion Hp eradication treatment can promote the platelet recovery in mild and moderate cITP patients with positive-Hp.