Application of parecoxib sodium for preemptive analgesia in patients undergoing cerebral angiography
10.3760/cma.j.issn.1673-4904.2011.12.002
- VernacularTitle:帕瑞昔布钠超前镇痛在全脑血管造影术中的应用
- Author:
Xiang ZHOU
;
Mingchun WU
;
Junzhe YANG
;
Xiaoyang SONG
- Publication Type:Journal Article
- Keywords:
Analgesia;
Cerebral angiography;
Parecoxib sodium
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(12):3-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of parecoxib sodium for preemptive analgesia in patients undergoing cerebral angiography. Methods Sixty patients undergoing cerebral angiography were divided into two groups by random digits table with 30 cases in each : group P and group F. Patients in group P received parecoxib sodium 40 mg 30 min before operation, while group F received fentanyl 1 μ g/kg 2 min before operation. The changes of hemodynamics were observed before operation (To), immediately right internal carotid artery angiography during operation (T1), immediately right vertebral artery angiography (T2),immediately left internal carotid artery angiography(T3), immediately left vertebral artery angiography(T4), 10min after operation (T5). The mean arterial pressure (MAP), heart rate (HR), pulse oxygen saturation (SpO2)and visual analogue score (VAS) were recorded at different times during the whole operation. Results There were no significantly differences on MAP, HR and VAS between group P and group F (P ＞ 0.05 ). But the SpO2 at T1 ,T2,T3 in group F (0.94±0.03,0.95±0.02,0.95±0.02) were significantly lower than those in group P (0.98 ± 0.01,0.98 ± 0.02,0.98 ± 0.02 )(P＜0.05 ), and 2 cases SpO2 ＜ 0.90 at Ti. Conclusion Parecoxib sodium administered preemptively provides a nice analgesic effect in patients undergoing cerebral angiography, and is more safe than fentanyl.
