The expression of tumor necrosis factor-α and its significance in different gestational period placentas and aging placentas

VernacularTitle:肿瘤坏死因子α在妊娠不同时期及老化胎盘组织中的表达及意义
Author: Xiaohong CHEN ; Yan WANG ; Ke ZHANG ; Xiaoyan DU
Publication Type:Journal Article
Keywords: Placenta aging; TNF-α; TNF-R
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(4):433-435
CountryChina
Language:Chinese
Abstract: ObjectiveTo study the differences of tumor necrosis factor-α in different gestational period placentas and aging placentas and to analyze its significances. MethodsUsing immunohistochemistry to detect the expression and distribution of tumor necrosis factor-α in different gestational period placentas and aging placentas. ResultsThe expression of tumor necrosis factor-α was significantly higher in the third trimester of pregnancy placentas and aging group than in the first trimester of pregnancy placentas(P＜0.05),and than in the second trimester of pregnancy placentas(P＜0.05).The expression of tumor necrosis factor-α had no significant difference between the third trimester of pregnancy placentas and aging group(P＞0.05). ConclusionTNF-α should play an important role in placental aging.