Optimizing extraction process of Chonglian oral solution by orthogonal test
10.3760/cma.j.issn.1008-6706.2011.04.002
- VernacularTitle:正交试验优选重连口服液的提取工艺
- Author:
Yongzhong WANG
;
Lunzhu XIA
;
Yirong FENG
;
Li CHEN
;
Mei MENG
- Publication Type:Journal Article
- Keywords:
Chonglian oral solution;
Extraction technology;
Orthogonal test;
Pariphyllin Ⅰ;
Phillyrin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(4):436-438
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo optimize Chonglian oral solution extracting craft. MethodsWith the obtaining rate of extract and the total content of the Pariphyllin Ⅰ and Phillyrin presented in the extract as the indexes for the water extraction process,and with the total content of the Pariphyllin Ⅰ and Phillyrin presented in the extract as the indexes for the alcohol deposition process,orthogonal design was used to optimize the conditions for the extraction process respectively. ResultsThe optimal conditions for the water extraction of Chonglian oral solution was as following:to add water 10 times,decocting 3 times,1 hour each time.The optimal conditions for the alcohol deposition of Chonglian oral solution was as following:concentrated for the relative density to 1.10(80C hot test),cold,add ethanol to the solution for the ethanol content of the solution reached 80%,static settlement for 24 hours. ConclusionThe extracting method is reasonable,stable,and suitable to industrialized producting.
