Clinical significance of serum IL-8 and TNF-α in patients with ulcerative colitis

VernacularTitle:溃疡性结肠炎患者血清白细胞介素8和肿瘤坏死因子-α的水平和意义
Author: Changwu WANG
Publication Type:Journal Article
Keywords: Colitis,ulcerative; Tumor necrosis factor-alpha; Interleukin-8
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(5):598-599
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical significance of serum IL-8 and TNF-α in patients with ulcerative colitis. Methods Enzyme-linked immunosorbent assay(ELISA) was used to detect the level of serum IL-8 and TNF-α in47 patiens wih active phase UC(severe stage 14 cases,medium stage 18 cases,mild stage 15 cases) ,21 patients with catabasis UC and 20 healthy individuals. Results The levels of IL-8 and TNF-α in patients with active phage UC were significantly higher than those of patients with catabasis UC and healthy individuals(P ＜ 0.05). The levels of IL-8 and TNF-α in patients with catabasis UC were higher than healthy individuals(P ＜0.05). The levels of IL-8 and TNF-α in severe UC were higher than those of patients with medium UC and mild UC (P ＜ 0.05). The levels of IL-8 and TNF-α in medium UC were higher than those of patients with mild UC (P ＜ 0.05). Conclusion The IL-8 and TNF-α may play an important role in the pathogenesis of UC. The combined levelsof serum IL-8 and TNF-α were potential markers in the evaluation of the activity and seriousness of UC.