Determination and application of Cytokeratin fragment 21-1, cancer antigen153, neuron-specific enolase in patients with lung cancer
10.3760/cma.j.issn.1008-6706.2011.05.004
- VernacularTitle:肺癌患者血清细胞角蛋白片断21-1、癌抗原153和神经特异性烯醇化酶的测定及应用价值
- Author:
Xiaotong WANG
;
Jing QIAN
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Keratins;
Antigens,neoplasm;
CD30 Ligand;
Phosphopyruvate hydratase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(5):584-586
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the contents of cytokeratin fragment 21-1 (CYFRA21-1),cancer antigen-153(CA153) and neuron-specific enolase (NSE)in patients wuth lung cancer. Methods 60 cases with lung cancer using single and combined determination serum CYFRA21-1, CA153 and NSE levels by radioimmunoassay (RIA). Results The contents of CYFRA21-1 ,CA125 and NSE in lung cancer were significantly higher than the control group(t = 2.811,2.845,2.901,2.795,2.759,2.811,2. 852,2.799,2. 816, all P ＜ 0. 01); The content of CYFRA21-1 in squamous cell carcinoma were higher than that small cell undifferentiated carcinoma(t = 2. 214, P ＜0. 05) ;The content of NSE in squamous cell carcinoma group were lower than small cell undifferentiated carcinoma (t = 2.312,P ＜ 0.05) ;The content of CA125 in adeno-carcinoma were higher than the higher squamous cell carcinoma scales cancer(t = 2. 177, P ＜ 0. 05); The positive rate of combined detection of CYFRA21-1 + CA153 + NSE (86. 4%)was significantly higher than the single test(x2 =3.786,P ＜0.05) ;The combined detection of sensitivity and negative predictive value was significantly higher than single detection (x2 = 3. 846,3. 877, all P ＜ 0. 05).Conclusion The combined determination could make up for missed diagnosis, and had some clinical value.
