Role of mTOR signaling pathway in the pathogenesis of pancreatic cancer
10.3760/cma.j.issn.1674-1935.2011.01.010
- VernacularTitle:mTOR信号通路在胰腺癌发病中的作用
- Author:
Hua JIANG
;
Xiaoying SHEN
;
Yanbing LIU
;
Xiaoyan ZHANG
;
Wujun XIONG
;
Hengjun GAO
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
mTOR;
Signaling pathway;
Gene expression profiling
- From:
Chinese Journal of Pancreatology
2011;11(1):28-30
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the expression of mTOR signaling pathway in pancreatic cancer and export its signification. Methods 6 samples of pancreatic cancer and its paracancerous tissues specimens confirmed by surgery and pathologic examination were selected. RNA was extracted and expression profiles experiment was performed by using Agilent human whole genomic oligonucleotide microarrays. The expression of mTOR signaling pathway in pancreatic cancer was analyzed by bioinformatics. Results Totally 1276 differential gene were selected, and 691 were up-regulated in cancer tissue, while 585 were down-regulated.The highest score of KEGG pathway's Enrichment and gene count was hsa04150 in mTOR signaling pathway,with its Enrichment of 4.5622519 and gene count of 9, and the percentage of gene count was 1.15%, the EASE Score P value was 6.23 E-04, which had the most biological significance. Among those, there was significantly difference of expression of nine key genes including ULK2, PIK3R3, PDPK1, EIF4EBP1, PGF,VEGFB, ULK3, RICTOR and PIK3 R5 (P ＜ 0.05). Conclusions The pathogenesis of pancreatic cancer is related to the activation of the mTOR signaling pathway.
