Meta-analysis on the relationship between 5-HTT gene polymorphism and depression

VernacularTitle:5-羟色胺转运体基因与抑郁症关系的Meta分析
Author: Shumin REN ; Shaoni LV ; Chuanxin LIU ; Xiutao HAN ; Qizhen ZHU ; Yongxiao TIAN
Publication Type:Journal Article
Keywords: Depression; 5-HTT; 5-HTTLPR; Genetics; Genes; Meta analysis
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(2):167-169
CountryChina
Language:Chinese
Abstract: Objective To assess the associations of 5-HTT gene polymorphism with depression by Metaanalysis.Method A comprehensive search for articles from January 2000 to July 2009 was conducted from Chinese BioMedical Literature Database on disc (CBMdisc) and PubMed databases.All related case-control studies were collected and the results were analyzed using RevMan 4.2.2 software.Results A total of 1284 cases and 1243 controls were collected from 14 studies.The combined data statistics revealed that the pooled ORs ( 95%CI) for genotype SS,SL,LL were 1.64 ( 1.37 ～1.97) (P＜0.00001),0.82 (0.66 ～ 1.03) (P＞0.01) and 0.74 (0.61 ～ 0.90) (P ＜ 0.01 ) respectively.Conclusions Polymorphisms of 5-HTT gene have significant association with depression,SS genotype may increase the risk for depression,LL genotype may be protective factors for depression.