Induction of imiquimod on IFN-γ in patients with condyloma acuminatum

VernacularTitle:咪喹莫特对尖锐湿疣患者血清干扰素-γ表达的影响
Author: Weizhong XIA ; Aiping LI ; Feng ZHANG ; Cuimei WANG
Publication Type:Journal Article
Keywords: Imiquimod; Condyloma acuminatum; IFN-γ; Real-time polymerase chain reaction
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(2):173-174
CountryChina
Language:Chinese
Abstract: Objective To study the induction of imiquimod on interferon-gamma (IFN-γ) in the peripheral blood of patients with condyloma acuminatum. Methods Twenty-two adult patients with condyloma acuminatum and twenty health control were sequentially enrolled in this study. Serum levels of IFN-γmRNA were measured by realtime polymerase chain reaction in 22 cases with condyloma acuminatum before and after treatment with imiquimod for 8 weeks and 20 health control. Results The serum level of IFN-γ mRNA before treatment was significantly lower than that of health control (t = - 2.87, P = 0.0071). Expression of serum IFN-γmRNA in condyloma acuminatum was significantly increased after 8 weeks imiquimod treatment (t = - 2.51 ,P = 0.0159). The serum level of IFN-γmRNA had no significant difference compared with after treatment group and health control group (t = - 1. 07, P =0. 2922). Conclusion Imiquimod could increase the low expression of IFN-γ mRNA in patients with condyloma acuminatum.