An analysis of treatment effects of intra-articular injection of sodium hyaluronate and diprospan on knee joint osteoarthritis
10.3760/cma.j.issn.1008-6706.2010.s1.003
- VernacularTitle:玻璃酸钠和二丙酸倍他米松/倍他米松磷酸二钠关节腔内注射治疗骨性关节炎的疗效分析
- Author:
Huading LU
;
Xiaoyue WEN
;
Chun ZENG
;
Daozhang CAI
;
Huiqing ZHAO
- Publication Type:Journal Article
- Keywords:
Sodium hyaluronate;
Betamethasone dipropionate/betamethasone phasphate;
Osteoarthritis knee;
Injection intra-articular
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(z1):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate and compare the clinical effects of intraarticular injection of sodium hyaluronate and diprospan on knee osteoarthritis. Methods 94 patients with knee osteoarthritis were divided into two groups, the HA group and Cortieosteroid group. Each patient in the HA group was treated with intra-articular injection of sodium hyaluronate at 2.5 ml every week for 5 weeks, and each patient in the Corticosteroid group was treated with intra-articular injection of diprospan at 1ml on the first and fourth week. The clinical assessments included pain,joint effusion,and Lequesne Index. Assessments were done at baseline, at week 4, and week 12. Results 88 cases were followed up for 3 months. A significant decrease in VAS scores for pain and in Lequesne Index was found in both groups at week 4 when compared to baseline and there were no significant differences between the two groups. However,at 12 week improvement in pain score and Lequesne Index was found in favour of hyaluronic acid. In addition,diprospan seemed to have preferable short-term effect on patient with joint effusion. Conclusion Both intra-articular injection of sodium hyaluronate and diprospan provided clinically significant improvement in short-term and demonstrated that hyaluronic acid had a more long-term beneficial effect in patients with knee osteoarthritis.
