The effect of butorphanol on vascular reactivity in lipopolysaccharide-pretreatment isolated rabbit pulmonary arteries
10.3760/cma.j.issn.1008-1372.2011.03.011
- VernacularTitle:布托啡诺对脂多糖诱导离体兔肺动脉反应性变化的影响
- Author:
Hongbo YU
;
Jin ZHANG
;
Xueqing DING
;
Dongyi TONG
;
Na LI
- Publication Type:Journal Article
- Keywords:
Butorphanol/PD;
Pulmonary artery/DE/PP;
Lipopolysaccharides/AE;
Shock/CI
- From:
Journal of Chinese Physician
2011;13(3):319-321
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regulatory roles of butorphanol on isolated rabbit pulmonary arteries by lipopolysaccharide(LPS)pre-incubation and assay the protective effect of ketamine on clinic sep tic shock patients.Methods Vascular ring tension detection technique was applied to observe the effect of butorphanol on the normal or lipopolysaccharide incubated pulmonaryvascular.Results In normal group, the final concentration of butorphanol(0.1 μmol,1μmol,10μmol,100μmol)were used to make pretreat ment- phenylephrine(PE)pulmonary artery relaxation.In LPS group,the effect of vasodilation of butor phanol was enhanced.Conclusions LPS can enhance the effect of butorphanol on pulmonary artery relaxa tion reaction.And the direct effect of butorphanol on pulmonary arteries was vasodilation.
