P53 and its downstream gene METTL-9 expression in colon cancer
10.3760/cma.j.issn.1008-1372.2011.03.017
- VernacularTitle:P53及其下游基因METTL-9在结肠癌中表达的研究
- Author:
Peng MA
;
Jun YAN
;
Chunfang WANG
;
Pengfei LI
;
Zhijing LONG
;
Mingming CHEN
- Publication Type:Journal Article
- Keywords:
Tumor suppressor protein P53/ME;
Colonic neoplasms/ME;
Genes
- From:
Journal of Chinese Physician
2011;13(3):337-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of P53 and mettl-9 gene in colon cancer tissues and inflammation tissues and normal adjacent tissues and study its relationship with colon cancer.Methods The morphologic situation of histiocyte after H.E.stained was observed.The real-time fluorescent quantitative PCR was applied to detect the gene expression of P53 and METFL-9.Results The expression of P53 gene in inflammation tissues was significantly higher than that in cancer tissues and adjacent tissues(P ＜0.05).The expression of P53 gene in cancer tissues was significantly lower than adjacent tissues and infiammation tissues.METTL-9 gene expression in inflammation tissues was significantly lower than cancer tissues and adjacent tissues(P ＜0.05).In cancer tissues,P53 gene and METFL-9 gene were negative related.Conclusions The mutations of P53 gene played an important role in the course of colon cancer,its downstream gene METTL-9 was highly expressed in colon cancer,and the 9-methyl-converting enzyme which produced by transcription and translation might lead gene hypermethylation in the colon cancer,and thereby promoted the development of colon cancer.
