Fascin expression in lung cancer and its clinical significance

VernacularTitle:Fascin在肺癌中的表达及临床探讨
Author: Zhiqiang ZHANG ; Yuepeng GUO ; Qiang ZHANG ; Xiaomei YUAN ; Weixia YU ; Chaohui LU ; Haiying MA
Publication Type:Journal Article
Keywords: Actins/ME; Lung neoplasms/ME
From: Journal of Chinese Physician 2011;13(3):343-345
CountryChina
Language:Chinese
Abstract: Objective To investigate Fascin expression in human lung cancer tissues and its clinical significance.Methods Immunohistochemistry was performed in 62 patients with different histological types and clinical stages of lung cancer and 92 cases with other malignant tumors.Fascin positive rate in each group was calculated and the differences of pathological characters between the two groups were analyzed.Results Fascin expression in lung cancer tissues was significantly higher than that in normal lung tissues(P ＜ 0.05),its expression varied by different clinical stage of lung cancer tissue differentiation.As differentiation degree decreased,Fascin positive rate increased.Fascin expression was independent with age,sex,smoking history(P ＞ 0.05).Fascin expression had no significant difference between lung cancer group and other tumor group(P ＞ 0.05).Conclusions Fascin expression raising might be common in malignant tumors.Fascin expression in lung tissues indicated the possibility of lung cancer.In lung tissue,high expression of Fasein was a sign of poor differentiation and malignant status of lung cancer.