Association analysis of central executive function with the functional polymorphisms in monamime oxidase A and dopamine-β-hydroxylase
10.3760/cma.j.issn.1674-6554.2011.04.001
- VernacularTitle:中央执行功能与单胺氧化酶A、多巴胺β羟化酶基因功能多态性的关联研究
- Author:
Pingyuan GONG
;
Kejin ZHANG
;
Xiaocai GAO
;
Fuchang ZHANG
- Publication Type:Journal Article
- Keywords:
Central executive function;
Monoamine oxidase A;
Dopamine-β-hydroxylase
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(4):289-291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the associations of the sub-components of central executive function ( inhibition, shifting and updating) with monoamine oxidase A ( MAOA ) and dopamine-β-hydroxylase ( DBH ).Methods The cognitive performance of the 719 healthy individuals,who were selected randomly from an university in Xi' an,was assessed by the world wide used paradigms of central executive function. Then, a populationbased study was performed to analysis the associations of central executive function with the 30-bp variable number tandem repeat and -C1021T in the promoters of MAOA and DBH ,respectively. Results The results indicated that the 30-bp variable number tandem repeat of MAOA was associated with the performance of inhibition and updating ( x2 = 4.82,4.50; P= 0. 03,0.03 ) in males. The reaction time of inhibition test was shorter in 3r genotype group ( (671.32 ±9.77 )ms) than that in 4r genotype group ( (706.61 ± 14.58 ) ms) ,and the indivudals with 3r genotype (47.85 ±0. 69) had more updating numbers than the indivudals with 4r (45.13 ± 1. 05). However, there was no significant association of the -C1021T and DBH with the components of excutive function (P＞0.05). Conclusion The present study suggests that the 30-bp variable number tandem repeat of MAOA contributs to the inhibition in males while -C1021T of DBH has no striking effects on the components of executive function in males and females.
