The effect of 3-n-butylphthalide on learning and memory abilities in vascular dementia rats

VernacularTitle:消旋-3-正丁基苯酞对血管性痴呆大鼠学习记忆能力的影响
Author: Yuzhen XU ; Lichen QIN ; Yunlin LIU
Publication Type:Journal Article
Keywords: 3-n-butylphthalide Vascular dementia; Learning and memory abilities
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(4):309-311
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of 3-n-butylphthalide (NBP) on learning and memory abilities in vascular demensia (VD) rats. Methods VD model rats was established by two-vessel method. 60 3-month-old Wistar male rats were randomly divided into VD group, sham-operate group and NBP group. Rats in NBP group were given NBP 120 mg · kg-1 · d-1 ,VD and sham-operate group were given equal quality vegetable oil.Morris water maze was used to assess the learning and memory abilities in each group and HE staining was used to observe the hippocampus morphology of the rats. Results The escape latency in hidden plat test was( (38.34 ±2.46 ) s, ( 14.83 ± 3.77s ), ( 75.74 ± 6.33 ) s ) and the original platform quadrant time was ( ( 26.45 ± 4.66 ) s,(35.21 ±3.78)s, ( 18.67 ±5.39)s) in NBP group,sham-operate group and VD group respectively. Compared to VD group, NBP group had obviously decreased escape latency in hidden plat test, increased original platform quadrant time and distinctly decreased the necrosis of the neurons in HE dyeing. Conclusion NBP can improve the learning and memory deficits in VD rats.