The correlation of cerebral perfusion characteristics and cognitive function on patients with unipolar and bipolar depression
10.3760/cma.j.issn.1674-6554.2011.04.014
- VernacularTitle:单、双相抑郁患者脑血流灌注特征及其与认知功能的相关性
- Author:
Erni JI
;
Nianhong GUAN
;
Houliang WANG
;
Jinpei ZHANG
;
Ying PENG
- Publication Type:Journal Article
- Keywords:
Depression;
Single photon emission computerized tomography;
Cognitive function
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(4):330-332
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation of cerebral perfusion characteristics and cognitive function on patients with unipolar and bipolar depression. Methods The r-CBF imaging was detected by SPECT forall subjects. Evaluated cognitive function of subjects using WAIS-CR and WMA, and analysed data using SPSS.Results Data showed that some regions in the brain, e.g. temporal lobe, frontal lobe, hippocampus, and basal ganglia, had significant alterations of r-CBF in depressed patients as compared with healthy controls (P ＜ 0. 05 ).Compared with UPD, BPD showed increased perfusion in basal ganglia ( 0,22.73%; 4.54%, 36. 36% ) (P ＜0.05 ). Furthermore there was no significant different incognitive deficits between UPD and BPD(P ＞ 0. 05 ) , and correlations between cognitive impairment and hypoperfusion of rCBF (P ＜ 0. 05 ). Conclusion There be exist difference in r-CBF between UPD and BPD. The perfusion of r-CBF in BPD is significantly increased than that in UPD,and it suggest that hyperperfusion in basal ganglia may be the biological basis when bipolar depression turning to manic.
