Association study of dopamine D1 receptor gene and cognitive function of first-episode schizophrenic patients

VernacularTitle:首发精神分裂症患者认知功能与多巴胺D1受体基因的关联研究
Author: Chen ZHANG ; Zezhi LI ; Zhiguo WU ; Jun CHEN ; Daihui PENG ; Yiru FANG ; Shunying YU
Publication Type:Journal Article
Keywords: Schizophrenia; Cognitive function; Dopamine D1 receptor; Polymorphism; Association study
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(3):224-226
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between cognitive function of first-episode schizophrenic patients and dopamine D1 receptor gene. Methods A total of 112 first-episode schizophrenic patients and 60 healthy controls were evaluated with Wechsler adult intelligence scale ( WAIS-R), Wechsler memory scale (WMS) and Wisconsin card sort test (WCST) ,and genotyped one polymorphism (rs4532) within DRD1 gene using TaqMan SNP genotyping assay. Results There were no significant differences on the frequencies of the genotypes and alleles of rs4532 polymorphism between patients with schizophrenia and normal controls ( x2 =2.90, P=0.35; x2 = 0.01, P= 0. 93 ). There were significant differences in all index of WCST between two groups (P ＜0.01 ). Patients with rs4532G allele had worse WCST performance than those without G allele ((60.9 ± 13.2)%vs (44.9 ±21.3)%, t=4.79, P=0.00002). Conclusion Rs4532 polymorphism of DRD1 gene may be associated with executive function impairment in schizophrenic patients.