The study of magnetic resonance spectrum about sensitive brain structure of the first episode depression
10.3760/cma.j.issn.1674-6554.2011.01.007
- VernacularTitle:首发抑郁症患者敏感脑结构的磁共振质子波谱分析
- Author:
Dongqing WANG
;
Yan ZHU
;
Yuefeng LI
;
Guohai LI
;
Jun LIU
;
Ying ZHU
;
Ruigen YIN
;
Qin WU
;
Yifeng LUO
;
Liang ZHAO
;
Lirong ZHANG
- Publication Type:Journal Article
- Keywords:
Depression;
Magnetic resonance spectrum;
Hippocampus;
Thalamus;
Anterior cingulate
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(1):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the brain's metabolism about the hippocampus, anterior cingulate and thalamus of first episode depressive patients. Methods Using proton magnetic resonance spectroscopy and 1 HMRS analyzing technology to detect multiple metabolic indices of the hippocampus, anterior cingulate and thalamus of 20 patients and 20 healthy persons, including N-acetylaspartate ( NAA), choline ( Cho ), myoinositol ( MI ), creatine(Cr). Results The ratios of MI/Cr of the bilateral thalamus of the depressive patients group decreased ( Left (0.23 ±0.13) ,(0.25 ±0.09), t=2.25, P=0.03,Right(0.33 ±0.15,0.34 ±0.04), t=2.42, P=0.02).The ratios of NAA/Cr and Cho/Cr of the bilateral hippocampus of the depressive patients group were both lower (NAA/Cr: Left t=3.06, P=0.004,Right t=3.54, P=0.001. Cho/Cr: Left t=2.94, P=0.006,Right t=4.02,P=0.001 ). The ratios of Cho/Cr and MI/Cr of the anterior cingulate of the depressive patients group were both significantly higher (NAA/Cr: t=3.12, P=0. 003;Cho/Cr: t=2.62, P=0.01). Conclusion The metabolic abnormalities of hippocampus, anterior cingulate and thalamus maybe constitute the nervous biochemical basis of first episode depression.
