Lung protection effect of intra-aortic protamine injection in infants underwent opening heart operation by cardiopulmonary bypass surgery

Baoying Meng; Qing Zhang; Tao Wang; Dingrong Shen; Le Peng; Chao MA; Xiaolan Pan; Yuanxiang Wang

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Lung protection effect of intra-aortic protamine injection in infants underwent opening heart operation by cardiopulmonary bypass surgery

VernacularTitle:经升主动脉注射鱼精蛋白的肺保护作用
Author: Baoying MENG ; Qing ZHANG ; Tao WANG ; Dingrong SHEN ; Le PENG ; Chao MA ; Xiaolan PAN ; Yuanxiang WANG
Publication Type:Journal Article
Keywords: Cardiopulmonary bypass surgery; Lung injury; Protamine; Infants
From: Clinical Medicine of China 2011;27(3):235-238
CountryChina
Language:Chinese
Abstract: Objective To study the protective effect of intraaortic protamine injection on lung in infants undergwent opening heart operation by cardiopulmonary bypass surgery. Methods Sixty infants (age ≤ 1 year,weight ≤ 10 kg)who accepted opening heart operation by cardiopulmonary bypass surgery were randomly assigned into 2 groups ( n = 30 in each group) reciving intra-aortic and intra-venous protamine injection respectively. P-peak, P-plate, CL, Oxygenation Index, the number of WBC and neutrophil segregated in lungs were compared between two groups before injecting protamine and 10 minutes, 1 hour, 3 hours after injecting protamine. The time of mechanical ventilation were compared as well. Results P-peak, P-plate, the number of WBC and neutrophil segregated in lungs of intra-aortic injection group significantly decreased than intra-venous injection group at 1 hour, 3 hours after injecting protamine (t =2.743, 3.512; 3.218, 3.469; 3.716, 5.243; 3.853,4. 783 respectively, Ps ＜ 0. 05 ), while the CL and Oxygenation Index increased significantly ( t = 3. 976,4. 267; 4. 557,4. 265 respectively, P ＜ 0. 05 ). The duration of mechanical ventilation follow operation in intraaortic injection group ( [8. 03 ± 5. 14] h ) was shorter compared with intra-venous injection group ( [10. 56 ±6.95]h) (t =2.599,P＜0.05). Conclusion By intra-aortic protamine injection the lung injury decreased significantly. It shows good protective effect on lung in infants underwent opening heart operation by cardiopulmonary bypass surgery.