Expression of cannabinoid receptor 1 in liver tissue of patients with chronic hepatitis B and its relationship with the serum levels of TGF-β1 and Leptin
10.3760/cma.j.issn.1008-6315.2011.02.002
- VernacularTitle:大麻素受体1在慢性乙型肝炎患者肝组织表达及与血清转化生长因子-β1和瘦素的关系
- Author:
Lihong YE
;
Chongkui WANG
;
Yuzhen LIU
;
Jianhua LU
;
Junliang HOU
;
Huixia GAO
;
Li YANG
;
Zhaoxia ZHAO
;
Bingshun LI
;
Erhei DAI
- Publication Type:Journal Article
- Keywords:
Chronic hepatitis B;
Cannabinoid receptor 1;
Liver fibrosis;
Transforming growth factor-β1;
Leptin
- From:
Clinical Medicine of China
2011;27(2):117-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe expression and location of cannabinoid receptor 1 (CB1) in liver tissue of patients with chronic hepatitis B (CHB) ,and analyze the relationship of it with the liver fibrosis score,the serum levels of TGF-β1 and Leptin. Methods Liver biopsies were performed in 118 patients with CHB.The expression of CB1 in liver tissue was observed by immune histochemical staining, and semi-quantitative analysis was carried out to devide the CB1 score into four grades: -, +, + +, + + +. Serum levels of TGF-β1 and Leptin were determined by ABC-ELISA double-antibody sandwich method. Results The expression of CB1 in liver tissue with CHB had significant relationship with the fibrosis score. As the expression of the CB1 increased, the fibrosis score became higher ( F = 23. 369,P = 0. 000). Moreover, the expression of CB1 in liver tissue with CHB had significant relationship with the serum levels of TGF-β1 and Leptin( F values were 8. 762 and 5. 749;P values were 0. 001 and 0. 027, respectively). Conclusion CB1 may play promotive role in the process of hepatic fibrosis through regulation of TGF-β1 and Leptin.
