Expression of human epidermal growth factor receptor 2 in breast cancer and its correlation with tumor necrosis factor-α
10.3760/cma.j.issn.1008-6315.2011.03.005
- VernacularTitle:乳腺癌中人类表皮生长因子受体-2的表达及其与肿瘤坏死因子-α的相关性研究
- Author:
Di ZHANG
;
Jiancheng TU
;
Hanning HU
;
Gui YANG
;
Xiaogai LI
;
Mingxia YU
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Human epidermal grouth factor recepter-2;
Tumor necrosis factor -α
- From:
Clinical Medicine of China
2011;27(3):239-241
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the expression of Human Epidermal Growth Factor Receptor 2 (HER-2) in breast cancer and its correlation with Tumor Necrosis Factor-α (TNF-α). Methods We used SABC method to detect the expression of HER-2 and TNF-α in 112 cases of primary breast cancer, and analyzed the association of HER-2 expression with clinicopathological features and TNF-α expression. Results The positive expression rate of HER-2 in breast cancer was 35.71% (40/112), of which, the expression rate was 35.05% (34/97) in 97 invasive tubic breast cancer, and 33.33% (2/6) in invasive lobular breast cancer,25.00% (1/4) in mucinous carcinoma, and 50. 00% (2/4) in intraductal carcinoma. There was no significant correlation between HER-2 and any clinicopathological features of primary breast cancer ( P ＞ 0. 05 ). The expression of HER-2 in breast cancer had no signiciant association with TNM stage, age, age of menarche,menopause, gravidity, parity and family history of cancer ( Ps ＞ 0. 05 ), The positive rate of TNF-α was 23.61% (17/72) when HER-2 was negative, whereas the positive rate of TNF-α was 52. 50% (21/40) when HER-2 was positive. The expression of HER-2 was signiciantly positively correlated with the expression of TNF-α (r = 0. 881, P ＜ 0. 05 ). Conclusion HER-2 expression had a positive correlation with TNF-α in breast cancer,but the specific mechanism is still unclear.
