Association of rs501120 and rs17465637 gene polymorphisms with coronary heart disease in the Chinese Han population
10.3760/cma.j.issn.1008-1372.2011.03.001
- VernacularTitle:rs501120、rs17465637在中国汉族人群中与冠心病的关系
- Author:
Liyun ZHANG
;
Yi ZHOU
;
Zhonghan HE
;
Manhua CHEN
;
Xiaomin ZHANG
;
Li ZHOU
;
Longxian CHENG
;
Tangchun WU
- Publication Type:Journal Article
- Keywords:
Polymorphism,single nucleotide;
Coronary disease/GE
- From:
Journal of Chinese Physician
2011;13(3):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the rs501120 and rs17465637 gene polymorphisms,and their relationship with the risk of coronary heart disease(CHD)in Chinese Han population.Methods 775 CHD without treatment and 775 age and gender matched controls were selected for this study,the genotypes of two single nucleotide polymorphisms(SNP)rs501120 and rs17465637 were tested with TaqMan-MGB probes.Results There was no significant difference in the frequency of genotypes of the 2 SNPs between CHD group and control group(P ＞0.05).Stratified analysis showed that SNP rs501120 had significant protection with CHD in people younger than 60 years old(OR 0.4,95% CI 0.2-0.9,P ＜ 0.05)or people with diabetes(OR0.3,95%CI0.1-0.7,P ＜0.05).Conclusions The results suggested that rs501120 was tightly associated with CHD in people younger than 60 years or had diabetes.
