Primary biliary cirrhosis associatied with polymyositis
10.3760/cma.j.issn.1007-7480.2011.03.008
- VernacularTitle:多发性肌炎合并原发性胆汁性肝硬化十例临床分析
- Author:
Li WANG
;
Lixia GAO
;
Fengchun ZHANG
- Publication Type:Journal Article
- Keywords:
Liver cirrhosis,biliary;
Polymyositis;
Dermatomyositis
- From:
Chinese Journal of Rheumatology
2011;15(3):172-174
- CountryChina
- Language:Chinese
-
Abstract:
Objective To address the clinical features of the overlap of polymyositis (PM) and primary biliary cirrhosis (PBC),as well as its similarities to and differences from PBC/nPM patients.Methods Medical charts of 10 cases of PBC/PM inpatients admitted to Peking Union Medical College Hospital (PUMCH) from October 1989 to October 2009 were systemically reviewed.Two hundred and twenty-three cases were included as controls from the database of PBC patients in PUMCH at the same period by the statistic methods of t test,x2 test or Fisher exact test.Results ① Ten (2.67%) PBC patients had concurrent PM.② Male/Female ratio in PBC/PM group was 3/7 and the age at diagnosis was (54±8) years.No significant differences between the two groupsin these data (P＞0.05).③ Clinical features and laboratory findings of PBC/PM included: cardiomyopathy in 4 cases,respiratory muscle involvement in 2 cases,level A of Child-Pugh classification in 9 cases,level C in 1 case,positive antinuclear antibody in 10 cases,positive anti-mitochondrial antibody in 10 cases,positive M2 subtype in 7 cases,elevated erythrocyte sedimentation rate(ESR)in 9 cases.④ The significant difference between the two groups was ESR (P=0.047).Conclusion The concurrence of PBC and PM is not rare,and the inflammation of PBC/PM is likely more prominent than PBC/nPM.
