Contrast-enhanced ultrasonography of hepatocellular carcinoma: correlation between quantitative parameters and arteries in neoangiogenesis

VernacularTitle:肝细胞癌的超声造影定量参数与肿瘤内新生动脉的相关性研究
Author: Xiaoqing PEI ; Longzhong LIU ; Feifei ZUO ; Wei ZHENG ; Yuhong LI ; Feng HAN ; Anhua LI
Publication Type:Journal Article
Keywords: Ultrasonography; Microbubbles; Carcinoma,hepatocellular; Neovascularization,pathologic
From: Chinese Journal of Ultrasonography 2011;20(3):222-225
CountryChina
Language:Chinese
Abstract: Objective To explore the relationships between the quantitative parameters for contrastenhanced ultrasonography(CEUS) in hepatocellular carcinoma (HCC) and arteries in neoangiogenesis.Methods One hundred and fifteen HCCs in CEUS were analyzed off-line with dynamic vascular curve of ImageArena and immunohistochemical stained in the tissue slices.Parameters including maximum of intensity(IMAX),rise time(RT),time to peak(TTP),mean trasit time corresponding to the center of gravity(mTT) ,rise slope(RS) and washout time(WT) were analyzed by statistics.Unpaired arteries(UAs)of 82 HCC cases were succesfully stained.Results The number of UAs had moderate correlation with RT (r = - 0.446),TTP (r = - 0.432) and RS (r = 0.431) (P ＜ 0.05),and it had mild correlation with IMAX (r = 0.303) ,WT (r = 0.285) (P ＜0.05).Conclusions Neoangiogenesis is a functional adaptation to altered vascular dynamics.Quantitative parameters of CEUS,reflecting hemodynamics of tumors,are correlated with UAs.