Initial study of acoustic radiation force impulse(ARFI) elastography quantification for evaluation of solid liver tumors
10.3760/cma.j.issn.1004-4477.2011.03.015
- VernacularTitle:定量声辐射脉冲弹性成像技术评价肝肿瘤特性的初步研究
- Author:
Gang WU
;
Qi WANG
;
Long YANG
;
Jianjun YUAN
;
Quan SHEN
;
Fei XUE
;
Bing ZHAO
;
Qiang TANG
;
Qiang WU
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Liver neoplasms;
Elasticity
- From:
Chinese Journal of Ultrasonography
2011;20(3):226-229
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the potential value of acoustic radiation force impulse (ARFI)elastography in the characterization of solid liver tumors.MethodsForty-three patients with 56 liver tumors were evaluated with ARFI,which included 21 patients with hepatocellular carcinoma (HCC),8 patients with metastase,5 patients with cholangiocarcinoma(CCC),and 9 patients with hemangioma.The shear wave velocity of the tumor and background liver parenchyma were calculated,and results were compared with 30 healthy subjects.Statistical analysis was performed on the shear wave velocity for differentiation of normal liver,background liver parenchyma,and tumors.ResultsHCC and CCC had greater stiffness than metastase (P ＜0.05),there were no statistical differences between HCC and CCC (P = 0.179).Malignant liver tumors had significantly greater stiffness than hemangioma and normal liver (P = 0.000).34.5% (9/26) HCC and 33.3% (4/12) hemangioma appeared softer than the background liver.With a cut-off value of 1.5 m/s for the shear wave velocity,the sensitivity,specificity,positive predictive value and negative predictive value for malignancies were 79.5%,83.3%,94.5% and 52.6%,respectively.ConclusionsARFI elastography quantification is a promising noninvasive technique for assessing solid liver tumors.Use of ARFI elastography quantification may lead to new quantitative tissue characterization parameters for differentiating hemangioma and malignant liver tumors.
