Dosimetric comparison of simulation treatment planning for thoracic esophageal carcinoma patients in contouring biological tumor volume with FLT and FDG PET-CT
10.3760/cma.j.issn.0254-5098.2011.01.011
- VernacularTitle:双示踪剂用于PET-CT图像勾画胸段食管癌生物靶区的模拟计划剂量学比较
- Author:
Dali HAN
;
Guifang ZHANG
;
Zheng FU
;
Jie LU
;
Xiaojun ZHONG
;
Shuqiang ZHAO
;
Xiaohui WANG
;
Qingzhen HOU
;
Yonghua YU
;
Jinming YU
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Radiotherapy;
Tomography;
Positron emission;
Biological tumor volumes;
Dosimetry
- From:
Chinese Journal of Radiological Medicine and Protection
2011;31(1):41-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate a feasibility of treatment planning in thoracic esophageal carcinoma with 3-deoxy-3-fluorothymidine (FLT) PET-CT and to compare with fluorodeoxyglucose (FDG) PET-CT based on dosimetric analysis.MethodsTwenty-two patients with esophageal squamous cell carcinoma detected by FLT and FDG PET-CT were enrolled.The gross tumor volumes ( GTV ),clinical target volume(CTV) and planning target volume ( PTV ) were delineated using treatment planning system of Philips Pinnacle3 based on the optimal threshold of FLT and FDG PET-CT respectively,and to make two groups simulation treatment planning.The parameters of dose-volume histograms in two groups planning were compared in the similar direction and ensuring prescribed dose line surround 95% target volume.Results The values of GTV,CTV and PTV in FLT PET-CT planning were less than those of FDG,that dose received by spinal cord in two planning were not significantly yet ( t = - 1.60,- 1.55,all P ＞ 0.05 ).While,the values in mean lung dose,V5,V10,V30,V40 and V50 of bilateral lung,mean heart dose,and V30 of heart in FLT PET-CT planning were significant lower than those of FDG( t = -5.442 - -2.637,all P ＜0.05).Conclusions Compared with FDG,FLT PET-CT based treatment planning brings potential benefits for lungs and heart.
