The immunologic response of T-cell in large B-cell non Hodgkin lymphoma
- Author:
Phan Chien Thang
- Publication Type:Journal Article
- Keywords:
Hodgkin lymphoma
- MeSH:
Lymphoma, Non-Hodgkin;
Lymphoma, Lymphoblastic;
immunology
- From:Journal Ho Chi Minh Medical
2003;7(4):215-219
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The authors conducted a retrospective study including 72 patients with non-Hodgkin lymphoma (NHL) with large B cell, to determine the percentage of CD3+, CD4+, CD8+, and natural killer cells by flow cytometry from the biopsy specimens before treatment, and compared these results to the patients’ outcomes. Results: the increased percentage of CD4 T cell in pretreated biopsy specimens correlated significantly to the patients’ outcomes. Patients with increased CD4+ had better 5-year survival than the others. Over 20% CD4+ cell infiltrated in the pretreated biopsy specimens were independent factors of non-recurrence. The increasing of active CD4+ in large B cell NHL offered a better prognosis, and was a background in immunologic therapy of B cell NHL
