A systematic review of the effect of radiofrequency ablation and percutaneous ethanol injection therapy on small hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2011.03.004
- VernacularTitle:射频消融与经皮无水乙醇注射治疗小肝癌临床效果比较的系统评价
- Author:
Quanbo ZHOU
;
Yanan LU
;
Rufu CHEN
;
Tiaohua XIAO
;
Jiajia ZHOU
;
Ning GUO
- Publication Type:Journal Article
- Keywords:
Radiofrequency ablation;
Percutaneous ethanol injection;
Treatment;
Small hepatocellular carcinoma;
Systematic review
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(3):189-193
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of radiofrequency ablation and Percutaneous Ethanol Injection in the treatment of small hepatocellular carcinoma (HCC). Methods We searched MED-LINE (1966-2009), EMBASE (1966-2009), CBMdisc (1978-2009), The Cochrane Library, Evidence Base Medicine Reviews (Ovid Edition), and Cancerlit (1993-2009). Date of last search: 30Jun 2009. There were no restrictions in language. Randomized controlled trials (RCTs) and nonRCTs (NRCT) were both included in this study, and the quality of each study included was assessed.Meta-analysis was performed using RevMan 4.2 software. Results Four RCTs and one NRCT met the inclusion criteria on RFA versus PEI in the treatment of small HCCs. Meta-analysis showed the following: complete tumor response rate, 3-year survival rate, 1-, 3-year tumor-free survival rates and 1-, 3-year local recurrence rates showed statistically significant difference in the RFA group than the PEI group(P＜0.05). The 1-year survival rate and the main complications of the two groups of patients were similar and they were not significantly different (P＞0. 055). Conclusions The results show that RFA resulted in better clinical outcomes than PEI in the treatment of small HCC larger than 2 cm, and no difference small HCC of 2 cm or less. The two modalities were safe and there were vey few adverse effects of the treatments.
