Expression of CD40 in spleen in cirrhotic portal hypertension and its clinical significance
10.3760/cma.j.issn.1007-8118.2011.04.011
- VernacularTitle:CD40在肝硬化门静脉高压症脾脏中的表达与临床意义
- Author:
Hongqiang CHEN
;
Shuguang ZHANG
;
Yu CHENG
;
Yuxin CHEN
- Publication Type:Journal Article
- Keywords:
Hypertension portal;
CD40;
Spleen;
Immunohistochemistry
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(4):302-304
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression and clinical significance of CD40 in the spleen of cirrhotic portal hypertension. MethodsExpression of CD40 was determined with S-P immunohistochemistry in spleen specimens from 50 cases of cirrhotic portal hypertension and 15 healthy individuals. ResultsThe CD40 positive rates in normal spleen and cirrhotic spleen were 86.7% and 36.0%, respectively. There was a significant difference between the 2 groups (P＜0.05). There was a negative correlation between the expression of CD40 and Child grades of liver function and cirrhotic splenic types(P＜0. 05). Conclusion CD40 might reflect the changes of splenic immune function,which might be one of more exact clinical examination indexes of splenic immune function.
