Expression and clinical significance of HMGA2 protein in urothelial bladder cancer
10.3760/cma.j.issn.1000-6702.2011.02.012
- VernacularTitle:膀胱尿路上皮癌组织中HMGA2蛋白表达及其临床意义
- Author:
Guoliang YANG
;
Lianhua ZHANG
;
Juanjie BO
;
Kailin HOU
;
Yinjie ZHU
;
Chao ZHANG
;
Haifeng JIANG
;
Yiran HUANG
- Publication Type:Journal Article
- Keywords:
Bladder cancer;
HMGA2;
Immunohistochemistry;
Diagnosis;
Prognosis
- From:
Chinese Journal of Urology
2011;32(2):115-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study was to explore the expression and significance of HMA2 in bladder cancer , analyze its correlations to clinicopathologic and recurrence of bladder cancer. Methods The expression of HMGA2 protein in 148 specimens of bladder cancer and 30 specimens of normal bladder tissues was detected by immunohistochemtry, its correlations to clinicopathologic features was analyzed. Results There was no expression of HMGA2 protein in normal bladder tissues,while the expression level of HMGA2 protein was getting higher with the increase of tumor pathology grade and stage. The positive rate of HMGA2 protein was 21.3% in G1 bladder cancer, 60. 3% in G2 bladder cancer, 82.1% in G3 bladder cancer, its difference is significant (P＜0. 001). It was significantly lower in non-muscle invasive bladder cancer than in muscle invasive bladder cancer (43.3% vs 72. 7%, P=0. 003). The patients were followed up for 2～95 months, patients of recurrence was 64,HMGA2 protein expression was significantly higher in patients with recurrence than with non-recurrence (54.7% vs 25.0%, P=0. 007). Conclusions The expression of HMGA2 protein was highly in bladder cancer, the positive rate of HMGA2 protein expression was related with classification,TMN stage and recurrence, but not with sex, age, tumor number (P＞0. 05). The detection of the expression of HMGA2 protein is in favor of diagnosis and prognostic evaluation of bladder cancer.
