Expression and its clinical significance of serum insulin-like growth factors in patients with clear cell carcinoma of kidney
10.3760/cma.j.issn.0254-9026.2011.03.013
- VernacularTitle:胰岛素样生长因子在肾透明细胞癌患者血液中表达及其临床意义
- Author:
Yi HE
;
Hua WANG
;
Renye DING
;
Jiandi LIU
;
Linfeng LU
;
Yanqin GU
;
Zhenhua JIANG
;
Zengfu YU
;
Yansong HOU
;
Hao CHEN
;
Lingfeng WU
- Publication Type:Journal Article
- Keywords:
Insulin-like growth factor Ⅰ;
Insulin-like growth factor Ⅱ;
Kidney neoplasms;
Adenocarcinoma,clear cell
- From:
Chinese Journal of Geriatrics
2011;30(3):223-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expressions of serum insulin-like growth factor (IGF)- Ⅰ ,Ⅱ and IGF binding protein (IGFBP) 3, 5 and to explore the clinical significances in patients with clear cell carcinoma of kidney. Methods Enzyme-linked immunosorbent assay (ELISA) methods were adopted to examine serum expressions of IGF-Ⅰ , Ⅱ and IGFBP 3, 5 in 40 cases with clear cell carcinoma of kidney (renal carcinoma group) and 16 cases with hydronephrosis (control group) from May 2007 to December 2009. Results IGF- Ⅰ , Ⅱ and IGFBP 3,5 in renal carcinoma showed higher expressions before operation (985. 7 μg/L, 1154.0 μg/L,46.6 μg/L and 9.6 μg/L, respectively)than after operation (431.4 μg/L, 632.6 μg/L, 26.7 μg/L, and 6.7 μg/L, respectively, all P＜0. 05 ～0.01). There were no significant differences in those indexes between pre- and post- operation in control group (P＞ 0. 05). Conclusions There are high expressions of serum IGF-Ⅰ , Ⅱ and IGFBP 3, 5 in renal carcinoma patients, and IGF- Ⅱ has clinical significance in diagnosis.
