Long-term prognostic value of N-terminal prosoma brain natriuretic peptide in patients with acute coronary syndrome
10.3760/cma.j.issn.0254-9026.2011.02.007
- VernacularTitle:N末端原脑钠肽对急性冠状动脉综合征患者远期预后的预测价值
- Author:
Zhiyong YI
;
Xiaoying LI
;
Zhixin JIANG
;
Yufa SUN
;
Zheng CHA
;
Yawei LIU
;
Fengyi YUAN
;
Xiangzhen YUAN
;
Qingyong LI
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Natriuretic peptide,brain;
Prognosis
- From:
Chinese Journal of Geriatrics
2011;30(2):109-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the long-term predictive value of serum concentration of N-terminal prosoma brain natriuretic peptide (NT-proBNP) in the early acute coronary syndrome (ACS). Methods The 164 patients firstly hospitalized and finally diagnosed as acute myocardial infarction (AMI) were selected, and then the serum concentration of NT-proBNP was determined in less than 12 hours. According to the 75 percentage points of serum concentration of NT-proBNP, the patients were divided into two groups: low concentration group (n = 123) and high concentration group (n = 41 ). The major adverse cardiac events (MACEs) were followed and compared at one month, six months and twelve months between low group and high group. Results At 1-, 6-, 12-month follow-up, the odds ratio (OR) of death event were 4.1, 5.6 and 4.0 in high group respectively, and the nonfatal heart failure occurred in 4, 4 and 7 patients in high group. Multiple factor logistic regression analysis showed that NT-proBNP was an independent risk factor of the MACEs at different periods including short time, middle time and long time in ACS patients (P＜0. 05). Conclusions NT-proBNP is a strong predictor of the long-term MACEs in patients with early ACS.
