Assessment of left ventricular hypertrophy and impaired diastolic function in elderly hypertensive patients by brain natriuretic peptide level in combination with tissue doppler imaging
10.3760/cma.j.issn.0254-9026.2011.02.008
- VernacularTitle:脑钠肽联合组织多普勒检查对老年高血压患者左室肥厚及舒张功能受损的评估
- Author:
Xiaoyun ZHENG
;
Zhigang ZHENG
;
Xiaoping ZHANG
;
Duan QIAN
;
Liping ZHANG
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide brain;
Ultrasonography,doppler,pulsed;
Echocardiography;
Hypertension;
Ventricular function brain
- From:
Chinese Journal of Geriatrics
2011;30(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical values of brain natriuretic peptide (BNP) in combination with TDI in diagnosing left ventricular hypertrophy (LVH) and impaired diastolic function in elderly hypertensive patients. Methods The 140 elderly hypertensive patients were divided into LVH group (n=69) and NLVH group (n=71). Control group consisted of 50 normal subjects. Plasma BNP level and index of echocardiography, including mitral peak flow velocity during early and late diastole (E, A), ratio of E/A, average peak velocities of six LV wall sites at mitral annuluses during early and late diastole (MEm, MAm), ratios of MEm/MAm and E/MEm were measured in all patients. The correlation of plasma BNP level with cardiac ultrasonographic findings was also examined. Results The level of BNP [(61.64±37.18)ng/L, (138. 65±30. 23)ng/L] and the ratio of E/MEm (11.3±1.83, 15.7±1.45) were significantly higher in NLVH group and LVH group than in normal group (P＜0. 05 or P＜0. 01). MEm [(6.32±0. 94)cm/s, (4.29±0. 91)cm/s]and MEm/MAm (0.76±0.19, 0.51±0. 11) were significantly lower in NLVH and LVH group than in normal group (P＜0.05 or P＜0. 01). The BNP level was negatively correlated with E/A, MEm and MEm/MAm (r=- 0. 294, r= 0. 387 and r= 0. 422, all P＜0. 01), and was positively correlated with LVMI and E/MEm (r=0.342, r=0.501, all P＜0.01). Conclusions Left ventricular diastolic function is impaired in elderly hypertension patients regardless of LVH or NLVH.Plasma BNP level in combination with echocardiography parameter is accurate to evaluate the LVHand impaired diastolic function in elderly hypertensive patients.
