Clinical significance of detecting serum vascular endothelial growth factor and endostatin levels for lung cancer early detection in elderly long-term smokers
10.3760/cma.j.issn.0254-9026.2011.02.011
- VernacularTitle:长期吸烟老年人检测血清血管内皮生长因子和内皮抑素对肺癌早期诊断的临床意义
- Author:
Wenbin ZHOU
;
Ming BAI
;
Tuanxin HUANG
;
Xianzhu HU
- Publication Type:Journal Article
- Keywords:
Lung neoplasmas;
Vascular endothelial growth factors;
Endostatins;
Smoking
- From:
Chinese Journal of Geriatrics
2011;30(2):125-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes and clinical significances of serum vascular endothelial growth factor (VEGF) and endostatin concentrations for early detection of lung cancer in elderly long-term smokers. Methods Serum VEGF and endostatin concentrations were determined in 52 elderly long-term smokers and 20 elderly non-smokers by enzyme linked immunoabsent assay (ELISA) or competitive enzyme immunoassay. The 52 elderly long-term smokers were divided into lung cancer group (n = 32) and non-lung cancer group (n = 20). Results The concentration of serum VEGF was markedly higher in lung cancer group [(15. 7±8. 0) ng/L] than in non-lung cancer group and normal control group (t= 13. 681, t= 9. 372, respectively, both P＜0. 01). And the level of serum VEGF was significantly higher in non-lung cancer group than in normal control group (t=5. 250, P＜0. 05). The level of serum endostatin was significantly higher in elderly long-term smokers with or without lung cancer than in normal control group (t=5. 332, t=3. 700, respectively, P＜0. 01 and P＜0.05). But there was no statistic difference between non-lung cancer group and lung cancer group (t = 0. 814, P＞ 0.05 ). Notably, the endostatin/VEGF ratio was lower in lung cancer group than in non-lung cancer group and normal control group (t= 6. 270, t= 7. 138, respectively, both P＜0.01), while there was no significant difference between non-lung cancer group and normal control group (t= 1. 022, P＞0.05). Conclusions These findings suggest that the periodic detection of serum VEGF and endostatin and endostatin/VEGF ratio, especially endostatin/VEGF ratio, is of clinical importance and can be used as an early diagnostic marker of lung cancer in elderly long-term smokers.
