Clinical significance of second transurethral resection in newly diagnosed patients with T1 urothelial cell carcinoma of the bladder
10.3760/cma.j.issn.0254-9026.2011.04.010
- VernacularTitle:首诊T1期膀胱尿路上皮癌患者二次经尿道膀胱肿瘤电切除术的临床意义
- Author:
Chao ZHANG
;
Lianhua ZHANG
;
Juanjie BO
;
Jianjun SHA
;
Jianwei LV
;
Jing LENG
;
Dongming LIU
;
Yiran HUANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Urologic surgical procedures
- From:
Chinese Journal of Geriatrics
2011;30(4):299-301
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of second transurethral resection (TUR) in patients with T1 urothelial cell carcinoma of the bladder.Methods The 142 cases with urothelial carcinoma were recruited.All patients underwent transurethral resection of bladder tumor (TURBT) and were diagnosed as stage T1 urothelial carcinoma of the bladder.The 68 of 142 cases underwent second TUR after the initial surgery.Tumor recurrence rate,progression rate and recurrence-free survival were compared.Results There were no statistical differences in age,gender,follow-up time,number of tumors,size of tumors or grade of tumors between patients with and without second TUR.Of the 68 cases that underwent second TUR,25 cases (36.8%) had residual tumor and 6 of them (8.8%) had muscle-invasive bladder cancer.After an average observation for 26.8 months,patients who underwent second TUR showed lower recurrence rate,higher recurrence-free rate and longer recurrence-free survival than patients without second TUR [37.1% vs.58.1%,x2=5.962,P=0.015;41% vs.35.1%,x2=8.502,P=0.004;21 months vs.12 months,U= 1584,P= 0.002].While the progression rate showed no statistical difference between them (14.5% vs.25.7%,x2 =2.570,P=0.109).Conclusions Second TUR provides an effective way to completely excise tumor.Second TUR is beneficial to the decrease of recurrence rate and improvement of recurrence-free survival.However,its effect on tumor progression needs further discussion.
