The clinical efficacy and safety of intravenous cefmetazole in treatment of 1522 patients with aspiration pneumonia
10.3760/cma.j.issn.0578-1426.2011.04.008
- VernacularTitle:头孢美唑治疗吸入性肺炎1522例的疗效与安全性
- Author:
Xingyi ZHANG
;
Qun LI
;
Xin ZHOU
- Publication Type:Journal Article
- Keywords:
Pneumonia,aspiration;
Cefmetazole;
Treatment outcome;
Safety
- From:
Chinese Journal of Internal Medicine
2011;50(4):295-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of intravenous cefmetazole in the treatment of patients with aspiratory pneumonia. Methods A multicenter, prospective and open-labeled trial was conducted. A total of 1522 patients were enrolled at the beginning, and only 1324 were evaluabled at the endpoint. The duration of treatment was 7-14 days. During the treatment and follow-up periods, we recorded any unexpected symptoms and abnormal laboratory tests. At last,we evaluated its efficacy and safety. Results The total effective rate of cefmetazole was 79. 8% (1056/1324). The total bacterial eradication rate was 75.0% ( 342/456 ) . The bacterial eradication rates of klebsiellar pneumonia, escherichia, staphyloccocus aureus and anaerobic bacteria were 78.2% (97/124), 80.8% (80/99), 89.0% (81/91), 9/11,respectively. Conclusions Cefmetazole is effective and safe in the treatment of aspiratory pneumonia.
