Effect of recombinant human connective tissue growth factor on the expression of membrane type-1 matrix metalloproteinase and matrix metalloproteinase 2 in human osteoblasts
10.3760/cma.j.issn.1000-6699.2011.03.016
- VernacularTitle:重组人结缔组织生长因子对人成骨细胞膜型基质金属蛋白酶1及基质金属蛋白酶2表达的影响
- Author:
Guoliang SUI
;
Yiqun PENG
;
Yuling HE
;
Muxu ZHAI
;
Eryuan LIAO
- Publication Type:Journal Article
- Keywords:
Recombinant human connective tissue growth factor;
Human osteoblast;
Membrane type-1 matrix metalloproteinase;
Matrix metalloproteinase-2
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Human osteoblast was treated with recombinant human connective tissue growth factor (rCTGF). This experiment showed that rCTGF increased membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 protein expression in a dose- and time-depentent manner in human osteoblasts. rCTGF induced activation of p38 MAPK in human osteoblasts. p38 MAPK inhibitor SB23058 abrogated the effect of rCTGF on the expressions of membrane type-1 matrix metalloproteinase and matrix metalloproteinase-2 in human osteoblasts.
