The expression and significance of p-IRE-1α in rat liver with insulin resistance

VernacularTitle:胰岛素抵抗大鼠肝脏组织p-IRE-1α的表达及意义
Author: Hongfei LUO ; Lina PEI ; Jian DU ; Jia LIU ; Ningning GUO ; Zhinan LIN ; Keying ZHANG
Publication Type:Journal Article
Keywords: Insulin resistance; Rats; Liver; Phosphorylation of the inositol requiring enzyme-1α
From: Chinese Journal of Endocrinology and Metabolism 2011;27(3):250-252
CountryChina
Language:Chinese
Abstract: Fed with high-fat diet and assessed by hyperinsulinemia-euglycemia clamp technique, rat models with insulin resistance were successfully induced. Compared with normal chow group ( NC ), serum concentrations of free-fatty acids(FFAs) and baseline insulin in high-fat diet group(HF) was higher( P＜0.05 ), the average glucose infusion rate from 60 to 120 min( GIR60-120 ) was lower( P＜0.01 ), and the expression of p-IRE-lα in the liver was higher( P＜0.05 ). Furthermore, the expression of p-IRE-1α in the liver was positvely correlated with the serum concentration of FFAs. All these data indicate that high-fat diet may induce endoplasmic reticulum stress in the liver by elevating serum concentration of FFAs, and may participate in the genesis of insulin resistance via p-IRE-1α.