Effect of p38MAPK in icariin induced osteoblast differentiation
10.3760/cma.j.issn.1000-6699.2011.02.007
- VernacularTitle:p38MAPK途径在淫羊藿甙促成骨细胞分化中的作用
- Author:
Hong LI
;
Yun ZHOU
;
Xiuzhen ZHANG
- Publication Type:Journal Article
- Keywords:
Icariin;
p38MAPK;
Cbfa1;
Osteoblasts;
Osteoporosis
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(2):122-124
- CountryChina
- Language:Chinese
-
Abstract:
This paper was aimed to investigate the effects of icariin on the expression of p38 mitogen activated protein kinase(MAPK)protein in rat osteoblasts cultured in vitro, to elucidate the signal transduction of icariin in preventing and treating osteoporosis. The results showed that p38MAPK could be activated by icariin within 5min, and Cbfal could also be upregulated, and SB203580, an inhibitor of p38MAPK pathway, could partly inhibit Cbfal upregulation by icariin.
