Association of complement component 3 and high-sensitive C-reactive protein with insulin resistance index (HOMA2-IR)in non-diabetic population
10.3760/cma.j.issn.1000-6699.2011.02.010
- VernacularTitle:非糖尿病人群中补体C3、超敏C反应蛋白与胰岛素抵抗指数(HOMA2-IR)相关性分析
- Author:
Bangqiong WANG
;
Qifu LI
;
Yuanjuan JIANG
;
Zhoujun LIU
;
Li ZHONG
;
Qingfeng CHENG
;
Hua QING
- Publication Type:Journal Article
- Keywords:
Insulin resistance;
High sensitive C-reactive protein;
Complement component 3
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and compare the association of serum levels of of complement component 3(C3)and high-sensitive C-reactive protein(hs-CRP)with insulin resistance in non-diabetic subjects. Methods 587non-diabetic Chinese were recruited. Weight, height, blood pressure, waist circumference, fasting plasma glucose,fasting serum insulin, blood lipids, C3 and hs-CRP were measured. HOMA index(HOMA2-IR)was calculated.Insulin resistance was defined as the upper quartile of HOMA2-IR. Results C3 and hs-CRP were significantly higher in subjects with insulin resistance compared with subjects without insulin resistance. After controlling for age, gender,body mass index, and waist circumference, C3 was positively and significantly correlated with HOMA2-IR(r = 0.19,P＜0.01). As C3 increased, subjects were 3.78(OR= 3.78, P＜0.05)times more likely to suffer from insulin resistance, after adjustment for age, gender, systolic blood pressure, diastolic blood pressure, total cholesterol,triglycerides,high-density lipoprotein cholesterol, and waist circumference. However, hs-CRP was not significantly correlated with insulin resistance. Conclusions Serum complement component 3 has a more marked association with insulin resistance than hs-CRP in non-diabetic Chinese.
