Adenoviral vector-mediated IGF-Ⅰ gene transfer protects NOD mice from diabetes
10.3760/cma.j.issn.1000-6699.2011.02.017
- VernacularTitle:胰岛素样生长因子Ⅰ基因转移对NOD鼠胰岛炎及胰岛β细胞凋亡的保护作用
- Author:
Aijing XU
;
Zhihong CHEN
;
Fei TIAN
;
Lihua YAN
;
Tang LI
- Publication Type:Journal Article
- Keywords:
Mice,inbred NOD;
Diabetes mellitus,experimental;
Insulin-like growth factor-Ⅰ;
Apoptosis
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(2):158-160
- CountryChina
- Language:Chinese
-
Abstract:
To explore the protective effect of adenovirus mediated IGF-Ⅰgene(Ad-IGF-Ⅰ)transfer on non-obese diabetic(NOD)mice. The results showed that the incidence of diabetes and degree of insulitis were significantly reduced in mice receiving Ad-IGF- Ⅰ . Treatment with Ad-IGF- Ⅰ significantly decreased apoptosis rate,expression of Fas and caspase-3, and increased expression of Bcl-xl. This study indicates the potential of IGF- Ⅰ gene therapy in protecting NOD mice from insulitis and apoptosis.