Adenoviral vector-mediated IGF-Ⅰ gene transfer protects NOD mice from diabetes

VernacularTitle:胰岛素样生长因子Ⅰ基因转移对NOD鼠胰岛炎及胰岛β细胞凋亡的保护作用
Author: Aijing XU ; Zhihong CHEN ; Fei TIAN ; Lihua YAN ; Tang LI
Publication Type:Journal Article
Keywords: Mice,inbred NOD; Diabetes mellitus,experimental; Insulin-like growth factor-Ⅰ; Apoptosis
From: Chinese Journal of Endocrinology and Metabolism 2011;27(2):158-160
CountryChina
Language:Chinese
Abstract: To explore the protective effect of adenovirus mediated IGF-Ⅰgene(Ad-IGF-Ⅰ)transfer on non-obese diabetic(NOD)mice. The results showed that the incidence of diabetes and degree of insulitis were significantly reduced in mice receiving Ad-IGF- Ⅰ . Treatment with Ad-IGF- Ⅰ significantly decreased apoptosis rate,expression of Fas and caspase-3, and increased expression of Bcl-xl. This study indicates the potential of IGF- Ⅰ gene therapy in protecting NOD mice from insulitis and apoptosis.