Study on the mechanism of SPARC in the development of insulin resistance
10.3760/cma.j.issn.1000-6699.2011.02.018
- VernacularTitle:SPARC在胰岛素抵抗发展中作用机制的研究
- Author:
Yuanyuan GUAN
;
Haiyan SONG
;
Liping ZHANG
;
Kun LI
;
Chunli DONG
;
Qiang LI
;
Yuqian SUN
- Publication Type:Journal Article
- Keywords:
SPARC;
Insulin resistance;
Fat;
Rats
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(2):161-164
- CountryChina
- Language:Chinese
-
Abstract:
RT-PCR, Western blot, and immunofluorescence were used to examine secreted protein acidic and rich in cysteine(SPARC)mRNA and protein expression in adipose tissue of rats. The results showed that the expression levels of SPARC mRNA and protein in adipose tissue of insulin resistant rats were higher than those of the normal ones(all P＜0.01). SPARC may play a role in the negative feedback regulation duning the development of insulin resistance.
