The role of neurokinin-1 receptor in anti-nociceptive effect of inhalation anesthetics in mice
10.3760/cma.j.issn.0254-1416.2011.01.012
- VernacularTitle:脊髓神经激肽-1受体在吸入麻醉药对小鼠抗伤害性效应中的作用
- Author:
Su YAN
;
Tijun DAI
;
Gongjian LIU
- Publication Type:Journal Article
- Keywords:
Receptors,neurokinin-1;
Spinal cord;
Anesthetics,inhalation;
Analgesia
- From:
Chinese Journal of Anesthesiology
2011;31(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of neurokinin-1 receptor (NK-1R) in the anti-nociceptive effect of enflurane, isoflurane and sevoflurane in mice. Methods Three hundred and twenty Kunming mice of both sexes weighing 20-25 g were randomly divided into4 groups (n =80 each): group normal saline (group NS);group enflurane (group E); group isoflurane (group I) and group sevoflurane (group S). Normal saline (NS) 1.0ml/kg, erflurane 0.5 ml/kg, isoflurane 0.4 ml/kg and sevoflurane 2.0 ml/kg were injected intraperitoneally in NS,E,I and S groups respectively. Each group was further divided into 4 subgroups receiving intrathecal NS 5 μl and Sar-SP (NK-IR agonist) 20, 40 and 80 ng respectively at 5 min after intraperitoneal injection of inhalation anesthetics. The anti-nociceptive effect of the inhalation anesthetics was assessed by tail flick latency (TFL) (the latency for removal of the tail from the path of heat source) and paw-licking time (PLT) after intraplantar formalin injection. Results lntraperitoneal enflurane, isoflurane and sevoflurane significantly prolonged TFL and shortened PLT. Intrathecal Sar-SP 20, 40 and 80 ng significantly shortened TFL dose-dependently but had no significant effeet on PLT as compared with control subgroup. Conclusion NK-1R is involved in the anti-nociceptive effect of enflurane, isoflurane and sevofluran on thermal pain but not chemical and inflammatory pain.
