Changes in cortisol secretion in the acute phase of traumatic brain injury
10.3760/cma.j.issn.0254-1416.2011.01.026
- VernacularTitle:脑创伤患者急性期皮质醇分泌的变化
- Author:
Yong YANG
;
Qing LI
;
Feng GAO
;
Yonghao YU
;
Yi CHEN
;
Guolin WANG
;
Xide ZHU
;
Jianning ZHANG
- Publication Type:Journal Article
- Keywords:
Traumatic brain injury;
Acute-phase reaction;
Hydrocortisone
- From:
Chinese Journal of Anesthesiology
2011;31(1):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in cortisol (COR) secretion in the acute phase of traumatic brain injury (TBI) .Method Seventy-five patients admitted to the hospital at 2-24 h after TBI were divided into 3 groups based on the Glasgow Coma Scale score: mild TBI group (group TBI1, n = 30), moderate TBI group (group TBI2, n = 12) and severe TBI group (TBI3, n = 33). Thirteen patients with cervical spondylosis or osteoma of the skull (admitted to the hospital at the same period) were regarded as control group (group C). Venous blood samples were taken on the first day after admission to measure the serum concentrations of total COR, adrenocorticotropin (ACTH) and corticosteroid-binding globulin (CBG). Free COR concentrations and free COR index were calculated. High blood COR was recorded. Result Compared with group C, the serum concentrations of total COR and ACTH, free COR levels and free COR index were significantly increased in TBI1, TBI2 and TBI3groups (P ＜ 0.05). The parameters mentioned above were significantly higher in TBI2 and TBI3 groups than in TBI1 group ( P ＜0.05). There was no significant difference in serum CBG concentrations among the four groups.The incidence of high blood COR was significantly higher in TBI1, TBI2 and TBI3 groups than in C group, and in TBI3 group thanin TBI1 and TBI2 groups (P ＜0.05). Conclusion COR secretion is increased in the acute phase of TBI and the level of COR secretion is related to the severity of brain damage.
