Effect of endovascular cooling on perioperative brain injury in patients undergoing intracranial aneurysm resection
10.3760/cma.j.issn.0254-1416.2010.12.003
- VernacularTitle:血管内降温对颅内动脉瘤切除术患者围术期脑损伤的影响
- Author:
Zhiping WANG
;
Fengxiang WANG
;
Hongsheng CHEN
;
Zhengquan YU
;
Rutong YU
- Publication Type:Journal Article
- Keywords:
Hypothermia,induced;
Intracranial aneurysm;
Brain injuries
- From:
Chinese Journal of Anesthesiology
2010;30(12):1416-1419
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of endovascular cooling on perioperative brain injury in patients undergoing intracranial aneurysm resection.Methods Sixteen Hunt-Hess Ⅱ -Ⅳ patients of both sexes aged 18-64 yr undergoing intracranial aneurysm resection were randomly divided into 2 groups(n = 8 each): mild hypothermia group(group MHT)and nonnothermia group(group NT).A CL-2295AE catheter was placed in the femoral vein after anesthesia induction to perform endovascular cooling.Bladder temperature was reduced to 34 ℃ and maintained for 24 h.The hemodynamic parameters were recorded during and after operation.Coagulantion function and electrolyte levels were determined at 24 h before operation and at 12 and 24 h after operation.The serum neuron-specific enolase(NSE)and S100B concentrations were determined at 1 d before operation and at 1,3and 7 d after operation by ELISA.Neurological function was assessed with GOS grade at 1 and 3 months after operation.Results There was no significant difference in hemodynamic parameters,electrolyte levels(Na+ ,K+ ,Ca2+)and coagulantion function(PT,APTT,Plt)between the two groups(P ＞ 0.05).The GOS grade was significantly higher,while serum NSE and S100B concentrations were significantly lower after operation in group MHT than in group NT(P ＜ 0.05).Conclusion Endovascular cooling(34℃,24 h)can reduce the brain injury safely and effectively during the perioperative period in patients undergoing intracranial aneurysm resection and improve the prognosis.
