Immunological adaptive response induced by low dose X-rays
- Author:
Guizhi JU
;
Xu SU
;
Chunhua SONG
;
Shuzheng LIU
- Publication Type:Journal Article
- Keywords:
low dose radiation;
immunological adaptive response
- From:
Journal of Jilin University(Medicine Edition)
1999;25(5):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To find out whether or not low dose radiation could induce resistance to challenge dose-induced depression of immune functions.Methods:The following techniques were employed in this experiment:flow cytometry with immunofluorescence for the expression of TCR/CD3 receptor,3H-TdR incorporation technique for the spontaneous proliferation of thymocytes and the mitogen-induced proliferation of splencoytes as well as a bioassay with CTLL cells for IL-2 production.Results:The following optimal conditions for the induction of immunological adaptive response were determined:0.025 to 0.1 Gy for the conditioning doses (D1),1.0 to 1.5 Gy for the challenge doses (D2),and 6 to 12 h for the intervals between D1 and D2.Conclusion:Immunological adaptive response could be induced by low dose radiation.
