Early plasma albumin and inflammatory factors changes in patients undergoing abdominal surgery
10.3760/cma.j.issn.1007-631X.2010.12.020
- VernacularTitle:腹部手术后早期血浆白蛋白及炎症介质变化的研究
- Author:
Shumin LI
;
Pengyuan XU
;
Yunyun CEN
;
Xiongzhi CHEN
;
Dali SUN
;
Weiming LI
;
Yuxing QI
;
Yijun LI
;
Qingwen XU
- Publication Type:Journal Article
- Keywords:
Surgical procedures,operative;
Albumins;
Tumor necrosis factor-alpha;
Interleukin-6
- From:
Chinese Journal of General Surgery
2010;25(12):1002-1004
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the changes of plasma albumin concentration and its correlation with that of blood inflammatory factors at the postoperative early stage in patients undergoing intraabdominal surgery. Methods From August 2008 to March 2009, 45 patients undergoing abdominal surgery were divided into three groups according to different types of operation with 15 cases in each group, cholecystectomy group( A), chole cystectomy plus common bile duct exploration group(B) and radical resection of alimentary duct maliguance group (C). Before the surgery and 12,24,48,72 h after operation, plasma albumin contentserum IL-6 and TNF-α concentration were measured. Results Postoperatively the content of plasma albumin did not change significantly in group A ( P ＞ 0.05 ), while that decreased after operation in group B and group C(P ＜0.01 ). The postoperative concentration of serum IL-6 and TNF-α increased in group A at 12, 24 h and 48 h after operation(P ＜0.01 ). In group B and group C IL-6 and TNF-α increased at all tested time point after operation ( P ＜ 0.01 ). The postoperative alterations of IL-6 and TNF-α were statistically different between the three groups at all time points(P ＜0.01 ). The content of plasma albumin was in a negative correlation with the concentration of IL-6 and TNF-α; ( r = - 0.376, P = 0.000; r =-0.772,P = 0.000). Conclusions The content of plasma albumin decreased at the early stage after major and moderate abdominal surgery. The content of plasma albumin was in a negative correlation with the concentration of inflammatory factors at the early stage after abdominal surgery.
